Hydrogels: Biocompatible Adhesives in Cornea Transplants

Hydrogels for Cornea Transplants. ‘In the July 19 edition of Bioconjugate Chemistry, Mark Grinstaff and his colleagues at Boston University and Duke University Medical Center describe a novel form of hydrogel that performed well enough in tests to suggest that it can reduce the number of sutures required in surgery. The team built on earlier work in which they developed a hydrogel, based on thiazolidine ligation between synthetic macromolecules, that was useful in repairing acute corneal wounds such as an incision to repair a cataract. The hydrogel worked well enough, but it only held for a few days before it deteriorated. Corneal wounds heal quickly, but transplants take much longer, so the team turned to another approach: pseudoproline ligations between a synthetic macromolecule called a dendron (containing a cysteine residue), and poly(ethylene glycol) (PEG), containing an aldehyde.’

Tags: Hydrogels, Cornea Transplants

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