Polyester Dendrimer as an Anticancer Drug Delivery Vehicle

Single-Dose Drug-Loaded Dendrimer Cures Mice of Colon Cancer. In a dramatic demonstration of the power of nanotechnology, a team of investigators has designed a nanoscale, polymeric drug delivery vehicle that when loaded with a widely used anticancer agent cures colon cancer in mice with a single dose. The researchers, led by Francis Szoka, Ph.D., of the University of California, San Francisco, and Jean Fréchet, Ph.D., of the University of California, Berkeley, published the results of these experiments in the Proceedings of the National Academy of Sciences USA. This current work represents a milestone in a concerted effort to design nearly every aspect of a nanoscale drug delivery vehicle in order to maximize the anticancer activity of the drug payload. To create their drug delivery vehicle, the investigators used a highly branched polymer, known as a dendrimer, that naturally forms nanoparticles with myriad sites for drug loading. In this particular case, the researchers created what they call a bow-tie polyester dendrimer, whose molecular structure somewhat resembles a bow-tie with two discrete halves.’

Foresight Nanotech Institute: Molecular Modeling of Dendrimers for Nanoscale Applications. ‘Dendrimers and hyperbranched polymers represent a novel class of structurally controlled macromolecules derived from a branches-upon-branches structural motif. Dendrimers are well defined, highly branched macromolecules that radiate from a central core and are synthesized through a stepwise, repetitive reaction sequence that guarantees complete shells for each generation, leading to polymers that are monodisperse.’

Michigan Nanotechnology Institute for Medicine and Biological Sciences: Dendrimers. ‘The Michigan Nanotechnology Institute for Medicine and Biological Sciences (M-NIMBS) is developing bio-active nanodevices based on dendrimeric architecture. The Institute is constructing biologically active nanodevices from dendrimers. Nanotechnology is a new field, and these are the first working biologically active nanodevices. These nanodevices are undergoing tests to determine their operating parameters and biological activity. Currently the Institute is testing nanodevices as smart therapeutics for cancer. The Institute is building a catalog of components, each of which individually performs a particular biological task and each of which can be combined with others to produce a vast array of nanodevices.’

Dendrimers – Technical Terms, A Review, Diagrams, and Links

Gallery of Dendrimers at Materials and Process Simulation Center (MSC)

Dendritic Polymers and Their Potential Applications

Center for Molecular Design and Recognition (CMDR) Database of references related to dendrimers

Tags: Dendrimers, Drug Delivery, Colon Cancer

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