Plugs: Nanoscale Chemical Reactors

Optimizing Medicinal Chemistry With Microfluidics and Mass Spectroscopy. ‘A standard procedure in drug research is to take a molecule that shows promising anticancer activity and create dozens, or even hundreds, of closely related molecules to determine if any of these chemically related relatives are safer or more effective than the original molecule. This molecular tinkering process, however, is time consuming and expensive. It can also be difficult to accomplish when the original molecule is in short supply, as is often the case with drug candidates obtained from plants or marine organisms.’

Microgram-Scale Testing of Reaction Conditions in Solution Using Nanoliter Plugs in Microfluidics with Detection by MALDI-MS.



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