Coffee and Exercise May Help Prevent Skin Cancer

Caffeine and Exercise Can Team Up to Prevent Skin Cancer. ‘Regular exercise and little or no caffeine has become a popular lifestyle choice for many Americans. But a new Rutgers study has found that it may not be the best formula for preventing sun-induced skin damage that could lead to cancer. Low to moderate amounts of caffeine, in fact, along with exercise can be good for your health.

Groups of hairless mice, whose exposed skin is vulnerable to the sun, were the test subjects in experiments in which one set drank caffeinated water (the human equivalent of one or two cups of coffee a day); another voluntarily exercised on a running wheel; while a third group both drank and ran. A fourth group, which served as a control, didn’t run and didn’t caffeinate. All of the mice were exposed to lamps that generated UVB radiation that damaged the DNA in their skin cells.

Some degree of programmed cell death, also known as apoptosis, was observed in the DNA-damaged cells of all four groups, but the caffeine drinkers and exercisers showed an increase over the UVB-treated control group. Apoptosis is a way in which cells with badly damaged DNA commit suicide – UVB-damaged cells in this case.

“If apoptosis takes place in a sun-damaged cell, its progress toward cancer will be aborted,” said Allan Conney, director of Rutgers’ Cullman Laboratory.

Compared to the UVB-exposed control animals, the caffeine drinkers showed an approximately 95 percent increase in UVB-induced apoptosis, the exercisers showed a 120 percent increase, while the mice that were both drinking and exercising showed a nearly 400 percent increase.’



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